Khaleel set the tone, removing skipper James Rew (10) and George Hill (0) off successive deliveries to trigger the slide.
He followed it up with the wicket of Chris Woakes (5), caught behind, reducing the Lions to 266 for 8 by lunch.
After the interval, Nitish Kumar Reddy broke Farhan Ahmed’s dogged resistance — his 87-ball 24 frustrating the visitors — to make it 279 for 9.
But from there India A struggled to break through with the final wicket stand between Josh Tongue and No 11 Eddie Jack, frustrating the visitors.
Tongue remained unbeaten on a resolute 36 (61 balls), while 19-year-old Jack — playing only his second first-class game — displayed remarkable composure under pressure.
The left-hander struck three boundaries and partnered for a gritty 48-run last-wicket stand that took England Lions past the 300-run mark, frustrating the Abhimanyu Easwaran-led side.
India A rotated their bowlers and even took the second new ball in the 81st over in pursuit of the final scalp.
Khaleel was brought back in an attempt to bag a five-for, but it was Anshul Kamboj (2/56) who eventually ended the resistance at the stroke of tea.
A full delivery angled in from around the wicket beat Jack’s defence and clipped the top of off-stump.
Tushar Deshpande (2/62) was also impressive, dismissing the obdurate Max Holden (7).
Brief Scores: India A: 348 vs England Lions 327 in 89 overs (Emilio Gay 71, Tom Haines 54, Jordan Cox 45, Josh Tongue 36 not out; Khaleel Ahmed 4/70, Anshul Kamboj 2/56, Tushar Deshpande 2/62). PTI TAP SSC SSC
